文献：Guo Lifei et al.Meta-Analysis of Clinical Efficacy of Pulsed Radio Frequency Energy Treatment.Annals of Surgery.POST AUTHOR CORRECTIONS, 31 January 2012.
パルス高周波エネルギー療法の比較試験論文25件（参加者1332人）を対象に、疼痛、浮腫、創傷治療への臨床効果をメタ解析で検討。票数計算法による評価では、いずれの治療についても肯定的転帰が中立および否定的転帰より多かった。対数変換によるP値の併合による評価では、疼痛緩和、浮腫軽減、創傷治癒に統計学的有意な効果が見られた。
Meta-Analysis of Clinical Efficacy of Pulsed Radio Frequency Energy Treatment
Guo, Lifei MD, PhD, FACS; Kubat, Nicole J. PhD; Nelson, Teresa R. MS; Isenberg, Richard A. MD
Published Ahead-of-Print
Abstract
Objective: To statistically evaluate published clinical efficacy data related to the use of pulsed radio frequency energy (PRFE) therapy in 3 clinical applications.
Background: Numerous clinical studies have reported efficacy outcomes for PRFE therapy use in the palliative treatment of both postoperative and nonpostoperative pain and edema, and for its use as an adjunctive wound-healing (WH) therapeutic. Although diverse in design and endpoint, these studies are amenable to systematic review using both a vote-counting and P-value combination meta-analytic technique.
Methods: A meta-analysis of efficacy outcomes reported in clinical trials was performed using a vote-counting procedure. In addition, when possible, the sum of logs method of P-value combination was used to determine a significance level for the combined evidence within each endpoint and clinical area.
Results: Of the 186 clinical articles identified after application of selection criteria, there were 25 controlled trials that met criteria for inclusion in vote-counting and P-value combination methods and were used for formal statistical analysis. In total, 1332 patients receiving PRFE treatment were studied. Vote-counting procedure applied to clinical outcomes from controlled studies resulted in a greater number of positive outcomes than neutral outcomes, and zero negative outcomes, for each of the clinical application groups evaluated. The sum of logs P-value method found statistically significant improvement in pain, reduction in edema, and improvement in WH outcomes.
Conclusions: On the basis of statistical evaluation of published clinical efficacy data, there is strong statistical evidence that PRFE therapy is effective in the treatment of postoperative and nonpostoperative pain and edema and in WH applications.
(C) 2012 Lippincott Williams & Wilkins, Inc
