文献：Cecilia S, et al.The Association Between Dietary Patterns at Midlife
and Health in Aging: An Observational Study.Ann Intern Med.
2013;159(9):584-591.

女性1万670人（中央値59歳）を対象に、中年期の食習慣と健康的な加齢の関連を横断的観察研究で調査。代替的健康的食事指数（AHEI）2010のスコアおよび代替的地中海食の順守が、通常の加齢に比べ健康的な加齢（重大な慢性疾患、認知・身体・精神の障害がなく70歳以上の生存）と関連した（傾向のP＜0.001、P＝0.002）。

The Association Between Dietary Patterns at Midlife and Health in Aging: An
Observational Study

Cecilia Samieri, PhD; Qi Sun, MD, ScD; Mary K. Townsend, ScD; Stephanie E.
Chiuve, ScD; Olivia I. Okereke, MD; Walter C. Willett, MD, DrPH; Meir
Stampfer, MD, DrPH; and Francine Grodstein, ScD

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Ann Intern Med. 2013;159(9):584-591.
doi:10.7326/0003-4819-159-9-201311050-00004

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Chinese translation

Background: Maintaining health and well-being in aging populations is
critical.

Objective: To examine the association between dietary patterns in midlife
and prevalence of healthy aging.

Design: Cross-sectional observational study.

Setting: Nurses' Health Study.

Participants: 10 670 women with dietary data and no major chronic diseases
between 1984 and 1986, when they were in their late 50s and early 60s
(median age, 59 years). Women provided information on health an average of
15 years later.

Measurements: Diet quality in midlife was ascertained using the Alternative
Healthy Eating Index-2010 (AHEI-2010) and Alternate Mediterranean diet
scores, averaged from 2 food-frequency questionnaires (1984 to 1986).
“Healthy” aging was defined as survival to 70 years or older with
maintenance of 4 health domains: no major chronic diseases or major
impairments in cognitive or physical function or mental health.

Results: After multivariable adjustment, greater adherence to the AHEI-2010
(upper vs. lower quintiles) in midlife was related to 34% (95% CI, 9% to
66%; P for trend < 0.001) greater odds of healthy versus usual aging.
Greater adherence to Alternate Mediterranean diet was related to 46% (CI,
17% to 83%; P for trend = 0.002) greater odds of healthy aging. When the 4
components of healthy aging were analyzed separately, the AHEI-2010 and
Alternate Mediterranean diet were significantly associated with greater
likelihood of no major limitations in physical function and mental health.

Limitations: Residual confounding was possible, although many confounding
factors were considered. Bias due to complex patterns of measurement error
within diet scores cannot be excluded.

Conclusion: Better diet quality at midlife seems to be strongly linked to
greater health and well-being in persons surviving to older ages.

Primary Funding Source: National Cancer Institute, National Institutes of
Health.

Topics
aging ; diet ; chronic disease

2013年11月7日　提供：Ann Intern Med